Key Publications (from a list of 150 papers)



Kandiah, Nagaendran, Choi, Seong Hye, Hu, Chaur-Jong, Ishii, Kenji, Kasuga, Kensaku, Mok, Vincent C.T. Current and Future Trends in Biomarkers for the Early Detection of Alzheimer’s Disease in Asia: Expert Opinion. Accepted for publication on 23 October 2022 in Journal of Alzheimer’s disease reports, 6(1), 699-710. DOI: 10.3233/ADR-220059

Ashwati Vipin, Chen Ling Koh, Benjamin Yi Xin Wong, Fatin Zahra Zailan, Jayne Yi Tan, See Ann Soo, Vaynii Satish, Dilip Kumar, Brian Zhiyang Wang, Adeline Su Lyn Ng, Hui Jin Chiew, Kok Pin Ng, Nagaendran Kandiah. Amyloid tau neurodegeneration profiles and longitudinal cognition in sporadic young onset dementia, Journal Of Alzheimer’s Disease, September 2022, 90 (2), 543-551. PMID: 36155511, DOI:10.3233/JAD-220448

Oh S.L., Zhou M.K., Chin, E.W.M., Amarnath, G., Cheah, C.H., … Kandiah, N… Chiam, K.H. Alzheimer’s Disease Blood Biomarkers Associated With Neuroinflammation as Therapeutic Targets for Early Personalized Intervention. 11 July 2022, Frontiers in Digital Health, 4 (875895). PMID: 35899035, DOI:10.3389/fdgth.2022.875895

Gurveen Kaur Sandhu, Fatin Zahra Zailan , Ashwati Vipin , Soo See Ann, Dilip Kumar, Kok Pin Ng, Nagaendran Kandiah. Correlation between plasma Oligomeric Amyloid Beta and performance on the language neutral Visual Cognitive Assessment Test in a Southeast Asian population. Journal of Alzheimer’s Disease. 2022 Jul 11.PMID: 35848029, DOI:10.3233/JAD-220484

Chia SY, Vipin A, Ng KP, Tu H, Bommakanti A, Wang BZ, Tan YJ, Zailan FZ, Ng AS, Ling SC, Okamura K, Tan EK, Kandiah N, Zeng L. Upregulated Blood miR-150-5p in Alzheimer’s Disease Dementia Is Associated with Cognition, Cerebrospinal Fluid Amyloid-β, and Cerebral Atrophy. J Alzheimers Dis. 2022 Jul 5. PMID: 35811521 doi:10.3233/JAD-220116

Kumar, D, Yatawara, C, Wang, BZ, Wong, B, Tan, Y.J, Zailan, FZ, Ng, KP, Kandiah, N. APOE E4 and confluent WMH have a synergistic effect on episodic memory impairment in prodromal dementia. 2022. Journal of Alzheimer’s Disease, 87 (3), 1-12. PMID: 35431245, DOI:10.3233/JAD-215556

X Xu, KA Chew, ZX Wong, AKS Phua… N Kandiah, CL-H Chen. The Singapore Geriatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol. (2022). The Journal of prevention of Alzheimer’s Disease, 9(1), 40-48. PMID: 35098972, DOI: 10.14283/jpad.2022.5

Soo SA, Zailan FZ, Tan JY, Sandhu GK, Wong BYX, Wang BZ, Ng ASL, Chiew HJ, Ng KP, Kandiah N. Safety and Usefulness of Lumbar Puncture for the Diagnosis and Management of Young-Onset Cognitive Disorders. 2022. Journal of Alzheimer’s Disease, 87 (Suppl 1), 1-10. PMID: 35275537, DOI:10.3233/JAD-215453



Vipin A, Satish V, Saffari SE, Koh W, Lim L, Silva E, Nyu MM, Choong TM, Chua E, Lim L, Ng ASL, Chiew HJ, Ng KP, Kandiah N. Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease. Alzheimers Res Ther. 2021 Nov 30;13(1):195. doi: 10.1186/s13195-021-00936-y. PMID: 34847922; PMCID: PMC8630908.

Wong FCC, Saffari SE, Yatawara C, Ng KP, Kandiah N; Alzheimer’s Disease Neuroimaging Initiative. Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals. J Alzheimers Dis. 2021;84(1):91-101. doi: 10.3233/JAD-210333. PMID: 34511497.

Ng KP, Cheng GH, Yatawara C, Rosa-Neto P, Gauthier S, Kandiah N; Alzheimer’s Disease Neuroimaging Initiative. Baseline Neurodegeneration Influences the Longitudinal Effects of Tau on Cognition. J Alzheimers Dis. 2021;82(1):159-167. doi: 10.3233/JAD-201425. PMID: 33998536.

Soo SA, Ng KP, Wong F, Saffari SE, Yatawara C, Ismail Z, Kandiah N. The Association Between Diabetes Mellitus and Mild Behavioral Impairment Among Mild Cognitive Impairment: Findings from Singapore. J Alzheimers Dis. 2021;82(1):411-420. doi: 10.3233/JAD-210037. PMID: 34024829.

Vipin A, Wong BYX, Kumar D, Low A, Ng KP, Kandiah N. Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional. Aging (Albany NY). 2021 Apr 16;13(8):10973-10988. doi: 10.18632/aging.202977. Epub 2021 Apr 16. PMID: 33861727; PMCID: PMC8109133.

Ng KP, Chiew HJ, Hameed S, Ting SKS, Ng A, Soo SA, Wong BYX, Lim L, Yong ACW, Mok VCT, Rosa-Neto P, Dominguez J, Kim S, Hsiung GYR, Ikeda M, Miller BL, Gauthier S, Kandiah N. Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research. Alzheimers Dement (N Y). 2021 Jan 15;6(1):e12085. doi: 10.1002/trc2.12085. PMID: 33490361; PMCID: PMC7810128.

Kandiah N, Chan YF, Chen C, Dasig D, Dominguez J, Han SH, Jia J, Kim S, Limpawattana P, Ng LL, Nguyen DT, Ong PA, Raya-Ampil E, Saedon N, Senanarong V, Setiati S, Singh H, Suthisisang C, Trang TM, Turana Y, Venketasubramanian N, Yong FM, Youn YC, Ihl R. Strategies for the use of Ginkgo biloba extract, EGb 761® , in the treatment and management of mild cognitive impairment in Asia: Expert consensus. CNS Neurosci Ther. 2021 Feb;27(2):149-162. doi: 10.1111/cns.13536. Epub 2020 Dec 22. PMID: 33352000; PMCID: PMC7816207.



Kumar D, Vipin A, Wong B, Ng KP, Kandiah N. Differential Effects of Confluent and Nonconfluent White Matter Hyperintensities on Functional Connectivity in Mild Cognitive Impairment. Brain Connect. 2020 Dec;10(10):547-554. doi: 10.1089/brain.2020.0784. Epub 2020 Nov 16. PMID: 33050714.

Koh, W., Lim, L., Low, A., Wong, B., Lim, L., Silva, E., …Kandiah, N. Development and validation of a brief visual based cognitive screening tool for dementia: the Visual Cognitive Assessment Test short-form (VCAT-S). Journal of Neurology, Neurosurgery, and Psychiatry. 91 (10), 1122-1123. DOI: 10.1136/jnnp-2020-323106. PMID:32732390.

Wong FCC, Yatawara C, Low A, Foo H, Wong BYX, Lim L, Wang B, Kumar D, Ng KP, Kandiah N. Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment. Transl Stroke Res. 2021 Apr;12(2):284-292. doi: 10.1007/s12975-020-00847-4. Epub 2020 Sep 7. PMID: 32894401.

Wang BZ, Zailan FZ, Wong BYX, Ng KP, Kandiah N. Identification of novel candidate autoantibodies in Alzheimer’s disease. Eur J Neurol. 2020 Nov;27(11):2292-2296. doi: 10.1111/ene.14290. Epub 2020 May 25. PMID: 32356904.

Low, A., Lim, L., Lim, L., Wong, B., Silva, E., …Kandiah, N. Construct validity of the Visual Cognitive Assessment Test (VCAT) – A cross-cultural language-neutral cognitive screening tool. International psychogeriatrics. 32 (1), 141-149. DOI: 10.1017/S1041610219000504. PMID: 31111797.



Low, A., Ng K.P., Chander, R.J., Wong, B., Kandiah, N. Association of Asymmetrical White Matter Hyperintensities and Apolipoprotein E4 on Cognitive Impairment. Journal of Alzheimer’s Disease, 70 (3), 1-12. DOI: 10.3233/JAD-190159. PMID: 31306121.

Low, A., Foo, H., Yong, T.T. Tan, L.C.S., Kandiah, N. Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson’s disease. Journal of Neurology, Neurosurgery and psychiatry, 90 (6), 681-687. DOI: 10.1136/jnnp-2018-319592. PMID: 30683708.



Yatawara C, Ng KP, Chander R, Kandiah N. Associations between lesions and domain-specific cognitive decline in poststroke dementia. Neurology. 2018 Jul 3;91(1):e45-e54. doi: 10.1212/WNL.0000000000005734. Epub 2018 May 25. PMID: 29802171.

Ng, A., Tan, Y.J., Yi, Z., Tandiono, M., Chew E.,… Kandiah, N. Targeted exome sequencing reveals homozygous TREM2 R47C mutation presenting with behavioral variant frontotemporal dementia without bone involvement. Neurobiology of Aging 68 (160).. E15-160.E19. DOI: 10.1016/j.neurobiolaging.2018.04.003. PMID:29748150.



Lim, L., Zhang, A., Lim, L., Choong, T., Silva, E.,… Kandiah, N. High Caregiver Burden in Young Onset Dementia: What Factors Need Attention? Journal of Alzheimer’s Disease. 61 (2), 537-543. DOI: 10.3233/JAD-170409. PMID: 29171995.



Kandiah N, Zhang A, Bautista DC, Silva E, Ting SK, Ng A, Assam P. Early detection of dementia in multilingual populations: Visual Cognitive Assessment Test (VCAT). J Neurol Neurosurg Psychiatry. 2016 Feb;87(2):156-60. DOI: 10.1136/jnnp-2014-309647. Epub 2015 Feb 17. PMID: 25691617.

Yatawara, C., Lim, L., Chander, R., Zhou, J., Kandiah, N. Depressive symptoms influence global cognitive impairment indirectly by reducing memory and executive function in patients with mild cognitive impairment. Journal of Neurology Neuosurgery and Psychiatry, 87 (12), 1375-1383. DOI: 10.1136/jnnp-2016-314191. PMID: 28103200.